Please wait while images are indexed. If you need an immediate response please email before trying our site. If you have found this site useful please donate to us.Cytokine and chemokine gene expression in the myocardium during left ventricular remodeling following coronary occlusion in the rat.
In order to determine the role of various cytokines and chemokines in the development of myocardial remodeling, we investigated temporal and spatial changes of interleukin 1beta, tumor necrosis factor alpha, and their receptors in the rat left ventricle. Acutely, interleukin 1beta was upregulated in the infarct area, with a 4-fold increase on day 3 and a further 5-fold increase on day 5. The inducible form of the IL-1 receptor type 1 was expressed throughout the remodeling process, with maximal expression on day 3. A similar time course and expression pattern was observed for tumor necrosis factor alpha. In contrast, the expression of both the non-inducible (type I) and the inducible (type II) IL-1 receptor was significantly decreased in the infarct area compared to sham control. Although the high levels of IL-1beta and TNF-alpha in the infarct area may contribute to the ongoing remodeling process, the sustained high expression of IL-1 receptor (type I) observed throughout the remodeling process suggests that this cytokine may have a beneficial role in post-infarction healing. Moreover, our data provide evidence that the cardiac production of chemokines is increased and the local expression of chemokine receptors is increased during acute and chronic myocardial remodeling.
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